Mechanisms of phosphorus homeostasis
Phosphorus (P) is a vital micronutrient for all organisms and plays a central role in many metabolic processes. It is essential for the balance between the synthesis of nucleic acids, energy metabolism and bone formation and resorption. In mammals, P homeostasis is subject to a variety of complex regulatory mechanisms, with bone serving as a P reservoir.
As part of the Leibniz ScienceCampus Phosphorus Research Rostock, we are investigating the genetic and physiological mechanisms of P homeostasis and their effects on the performance and health of animals in order to ensure their efficient supply of the valuable P resource. We are investigating the effects of different P supplementations in pigs and chickens in order to systematically demonstrate metabolic reactions at the transcriptional, physiological and structural level. Gene expression analyses provide new insights into the relationships between P supplementation, bone metabolism and immune parameters.